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2020-05-14 10:47:16

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* ÁÖÁ¦ : Highly efficient RNA-guided base editing

ABSTRACT:

 
Point mutations caused by nucleobase deamination are a major source of human genetic disorders and diversity. Unlike mutagens causing random nucleobase deamination, RNA-programmable deaminase systems, composed of a catalytically impaired CRISPR–Cas9 variant (D10A Cas9 nickase (nCas9) or catalytically deficient D10A/H840A Cas9 (dCas9) from S. pyogenes) and a deaminase protein from various sources, enable single-nucleotide conversions or base editing in cells and organisms in a gRNA-dependent manner. These base editing systems can be divided into two categories: cytosine base editors (CBEs) that convert a C:G base pair to a T:A pair and Adenine base editors (ABEs) that convert a A:T pair to a G:C pair. Here we demonstrated the application of this technology in mouse embryos and adult mice











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